212 Use of Vitamin A on Developmental Studies in Ruminant Animals

Abstract Adipogenesis of intramuscular fat tissue in ruminant animals occurs from late pregnancy to first months age. Therefore, the potential (IMF) deposition lasts fetal phase until weaning. This crucial period is known as marbling window. Marbling stablished by both hyperplasia and hypertrophy processes, this attribute can be modulated a strategic nutrient plan or bioactive compounds. Some studies showed that angiogenesis process has specific relationship, spatially temporally, associated with adipogenesis. Adipose vastly vascularized capillaries surrounding each adipocyte fact turns target for manipulation, due pericytes blood vessel’s cell wall differentiating into pre-adipocytes adipocytes. Thus, manipulation processes related IMF have been studied active form vitamin A (retinoic acid) demonstrated modulator key genes expression. However, there are still some remaining questions concerning adequate dosage its best administration time point. In Korean native cattle, they found supplementation increased, progeny, birth weight upregulated expression preadipocyte muscle development. When supplemented via oral newborn calves, observed an improvement calf performance upregulation pre-adipogenic myogenic genes. research conducted United States using Angus it was neonatal injections, at 30 d age, promoted growth development beef cattle. mentioned above were myogenic, angiogenic adipogenic genes, also increase formation. our recent study Brazil, just one injection crossbred cattle we involved lipogenesis. summary, through during gestational period, possible upregulate several biological (myogenesis, angiogenesis, adipogenesis lipogenesis) deposition. Further needed confirm if pregnant cows results similar better outcomes progeny dosages recommendations injected calves.